Back to search

Article

PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells

2024-02-16

Abstract excerpt

Breast cancer develops upon sequential acquisition of driver mutations in mammary epithelial cells; however how these mutations collaborate to transform normal cells remains unclear in most cases. We aimed to reconstitute this process in a particular case. To this end, we combined the activated form of the PI 3-kinase harboring the H1047R mutation with the inactivation of the histone lysine methyl-transferase KMT2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a2097e74-5bed-56da-8352-7a1432e01e63
DOI
10.20944/preprints202402.0907.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial CellsDOI 10.20944/preprints202402.0907.v1
PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells.Semantic proximity
Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer.Semantic proximity
Oncogenic Alterations in PI3K Signaling Emulated Optogenetically Recapitulate Some Phenotypic Changes in Mammary Epithelia.Semantic proximity
Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation.Semantic proximity
MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells.Semantic proximity
MK3 modulation affects BMI1-dependent and independent cell cycle check-points.Semantic proximity
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation.Semantic proximity
Distinct roles of tumor associated mutations in collective cell migration.Semantic proximity
PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions.Semantic proximity
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells.Semantic proximity
Select a neighboring publication to make it the new centre.