Article

Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response

2025-07-29

Abstract excerpt

Pathogenic bacteria rely on the stringent response to adapt to the complex and fluctuating conditions encountered within the host. However, the mechanisms by which the stringent response senses host-induced stress remain poorly understood. Here, we identify iron–sulfur (Fe–S) cluster damage as a conserved trigger of the stringent response in major Gram-negative pathogens, including Salmonella enterica , Enteroba...

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Literature Corpus work: a1fa6f6b-63e4-56b4-93cf-3b80d4288072
DOI: 10.1101/2025.07.29.666095

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