Article

Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

2022-04-25

Abstract excerpt

<h4>Background: </h4> SMAD4 is a key mediator of TGFβ signaling and one of the mutated genes in extrahepatic bile duct cancer (eBDC). SMAD4 has dual functions, in carcinogenesis via silencing and in tumor invasion/metastasis via signaling, depending on tumor stage. We investigated the localization of functional SMAD4 (e.g., invasion or metastasis) and its association with chemo-radiation therapy. <h4>Methods: </h4...

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Literature Corpus work: a1ed3713-5f0d-54a1-96d6-95c4c89ddba5
DOI: 10.21203/rs.3.rs-1577386/v1

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