Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq

Abstract excerpt

A common objective across ATAC-seq and ChIP-seq analyses is to identify differential signals across contrasted conditions. However, in differential analyses, the impact of copy number variation is often overlooked. Here, we demonstrated copy number differences among samples could drive, if not dominate, differential signals. To address this, we propose a pipeline featuring copy number normalization. By comparing t...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Computer Simulation
• DNA Copy Number Variations
• Gene Dosage
• Genetic Variation
• Genome, Human
• Genomics
• Neoplasms

Identifiers and source

Literature Corpus work

a1d66a2d-acd2-5e50-a305-85e1983915c5

DOI

10.1101/2024.04.11.588815