Article

Transcription dosage compensation does not occur in Down syndrome

2023-06-09

Abstract excerpt

<h4>Background:</h4> Trisomy 21, also known as Down syndrome, describes the genetic condition of having an extra copy of chromosome 21. The increase in DNA copy number has led to the "DNA dosage hypothesis", which claims that the level of gene transcription is proportional to the gene’s DNA copy number. Yet many reports have suggested that a proportion of chromosome 21 genes are dosage compensated back towards ty...

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Literature Corpus work: b372e83a-1c85-5813-a710-177a574c8c63
DOI: 10.1101/2023.06.07.543933

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