Article

Fine-tuning of leaky expression delivers soluble and functional recombinant alphainterferon in the cytoplasm of Escherichia coli

2025-12-17

Abstract excerpt

Alphainterferons are cytokines that became famous in the treatment of certain infections and tumors due to their antiviral, antiproliferative, and immunomodulatory activities. These small proteins have been successfully manufactured in transformed Escherichia coli, but as commonly seen in biotech industries, overexpression leads to insoluble inclusion bodies that need to be processed through costly and lengthy ste...

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Literature Corpus work: a1c9e684-1f1e-53cb-8eff-219a715b07b9
DOI: 10.22541/au.176599216.69219166/v1

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Fine-tuning of leaky expression delivers soluble and functional recombinant alphainterferon in the cytoplasm of Escherichia coliDOI 10.22541/au.176599216.69219166/v1Read

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