Article

Antagonism Rather Than Synergy: Ibuprofen-Antifungal Interactions Depend on Strain Genetics and Nutrient Environment

2026-01-22

Abstract excerpt

Drug interaction outcomes-synergism, additivity, or antagonism-represent complex phenotypes. While drug repurposing aims to identify compounds that potentiate conventional antifungals, when given in combination, the modulators of these interactions in fungi remain largely unexplored. We hypothesize that the response to repurposed-conventional antifungal pairs is a complex trait modulated by genetic and environment...

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Literature Corpus work: a1c4c6c6-b4f0-573a-9bf8-a7a892ff4b84
DOI: 10.64898/2026.01.22.701080

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