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Article

Artemisinin elevates ergosterol levels of Candida albicans to synergise with amphotericin B against oral candidiasis.

International journal of antimicrobial agents - 1 Sept 2021

Zhu Chengguang, Liao Binyou, Ye Xingchen, Zhou Yujie, Chen Xi, Liao Min, Cheng Lei, Zhou Xuedong, Ren Biao

Abstract excerpt

Oral candidiasis, especially caused by Candida albicans, is the most common fungal infection of the oral cavity. The increase in drug resistance and lack of new antifungal agents call for new strategies of antifungal treatment. This study repurposed artemisinin (Art) as a potentiator to the polyene amphotericin B (AmB) and characterised their synergistic mechanism against C. albicans and oral candidiasis. The...

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Identifiers

PMID: 34197906
DOI: 10.1016/j.ijantimicag.2021.106394

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