Article

An optimized protocol for generating and monitoring conditional orthotopic lung cancer in the KP mouse model at BSL-1

2023-03-21

Abstract excerpt

<h4>Background: </h4> The inducible Kras/p53 lung adenocarcinoma mouse model, which faithfully recapitulates human disease, is routinely initiated by the intratracheal instillation of a virus-based Cre recombinase delivery system. Handling virus-based delivery systems requires elevated biosafety levels, e.g., biosafety level 2 (BSL-2). However, in experimental animal research facilities, following exposure to vira...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a1b6486c-896f-5a7b-90eb-9b27c64a98dd
DOI: 10.21203/rs.3.rs-2696461/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An optimized protocol for generating and monitoring conditional orthotopic lung cancer in the KP mouse model at BSL-1DOI 10.21203/rs.3.rs-2696461/v1Read

An optimized protocol for generating and monitoring conditional orthotopic lung cancer in the KP mouse model at BSL-1Semantic proximity Read

A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse ModelsSemantic proximity Read

Versatile and enhanced tumour modelling in mice via somatic cell transduction.Semantic proximity Read

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.Semantic proximity Read

Detection of Lung Tumor Progression in Mice by Ultrasound Imaging.Semantic proximity Read

Characterization of A Bronchoscopically Induced Transgenic Lung Cancer Pig Model for Human TranslatabilitySemantic proximity Read

Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung.Semantic proximity Read

“Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models.”Semantic proximity Read

The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice modelsSemantic proximity Read

Of Mice and Humans: Are They the Same?—Implications in Cancer Translational Research: TABLE 1Semantic proximity Read

Multi-scale in vivo imaging of tumour development using a germline conditional triple-reporter systemSemantic proximity Read