Article

An optimized protocol for generating and monitoring conditional orthotopic lung cancer in the KP mouse model at BSL-1

2023-03-14

Abstract excerpt

<h4>Background: </h4> The inducible Kras/p53 lung adenocarcinoma mouse model, which faithfully recapitulates human disease, is routinely initiated by the intratracheal instillation of a virus-based Cre recombinase delivery system. Handling virus-based delivery systems requires elevated biosafety levels, e.g., biosafety level 2 (BSL-2). However, in experimental animal research facilities, following exposure to vira...

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Literature Corpus work: 45043de5-2bca-52ae-a625-16f62f67b79b
DOI: 10.21203/rs.3.rs-2668687/v1

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