Article

E2F1-mediated repression of WNT5A expression Promotes Brain Metastasis Dependent on the ERK1/2 pathway in EGFR-Mutant Non-Small Cell Lung Cancer

2020-05-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Brain metastasis (BM) is associated with poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutation reportedly enhances the development of BM. However, the exact mechanism of how EGFR-mutant NSCLC contributes to BM remains unknown. This study was aimed at exploring the mechanism of BM development...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a178dd93-417e-50c9-b10f-2a0498923d35
DOI: 10.21203/rs.3.rs-30032/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

E2F1-mediated repression of WNT5A expression Promotes Brain Metastasis Dependent on the ERK1/2 pathway in EGFR-Mutant Non-Small Cell Lung CancerDOI 10.21203/rs.3.rs-30032/v1Read

E2F1-mediated repression of WNT5A expression promotes brain metastasis dependent on the ERK1/2 pathway in EGFR-mutant non-small cell lung cancer.Semantic proximity Read

WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.Semantic proximity Read

Advances in Lung Cancer Driver Genes Associated With Brain MetastasisSemantic proximity Read

Wnt5b-induced PCP/JNK Activation Promotes PD-L1 Expression and the Malignant Phenotype of Non-small Cell Lung Cancer Semantic proximity Read

Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4Semantic proximity Read

Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expressionSemantic proximity Read

Wnt5a Expression Is Associated With the Tumor Proliferation and the Stromal Vascular Endothelial Growth Factor—An Expression in Non–Small-Cell Lung CancerSemantic proximity Read

Wnt signaling as potential therapeutic target in lung cancerSemantic proximity Read

Epigenetic silencing of miR-145-5p contributes to brain metastasisSemantic proximity Read

Bone metastasis unique plasma exosomal microRNA signature in non-small cell lung cancerSemantic proximity Read

RBM10 Interacts with CTBNNBIP1 and Represses Lung Adenocarcinoma Progression Through the Wnt/β- catenin PathwaySemantic proximity Read

ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5Semantic proximity Read