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Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4

28 May 2025

Abstract excerpt

PURPOSE: Among malignant tumors, non-small cell lung cancer (NSCLC) remains a major threat to human life and health. Studies have illustrated that minichromosome maintenance protein 4 (MCM4) has complex interactions with the progression of many cancers, yet the role and mechanism of MCM4 in NSCLC remain to be elucidated. METHODS: MCM4 expression in NSCLC tissues was assessed using the TCGA database. MCM4 levels...

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Cancer-related Molecular Pathways
DNA Repair Mechanisms
Microtubule and mitosis dynamics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40437556
DOI: 10.1186/s13019-025-03481-z

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