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Article

Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression

18 Oct 2012

Abstract excerpt

BACKGROUND: As one of the malignant tumors most often affecting children and young adults, Ewing sarcoma (ES) is characterized by early metastasis contributing to unfavorable prognosis. However, the molecular mechanisms responsible for ES metastasis remain poorly understood. In this study, we aimed to explore whether Wnt5a, a putative pro-metastatic factor, plays a role in ES metastasis. METHODS: Expression of...

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Share to Chemokine receptors and signaling
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 23075330
DOI: 10.1186/1471-2407-12-480

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