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Article

E2F1-mediated repression of WNT5A expression promotes brain metastasis dependent on the ERK1/2 pathway in EGFR-mutant non-small cell lung cancer.

Cellular and molecular life sciences : CMLS - 1 Mar 2021

Li Huanhuan, Tong Fan, Meng Rui, Peng Ling, Wang Jiaojiao, Zhang Ruiguang, Dong Xiaorong

Abstract excerpt

Brain metastasis (BM) is associated with poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutation reportedly enhances the development of BM. However, the exact mechanism of how EGFR-mutant NSCLC contributes to BM remains unknown. Herein, we found the protein WNT5A, was significantly downregulated in BM tissues and EGFR-mutant samples. In...

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Identifiers

PMID: 33078208
DOI: 10.1007/s00018-020-03678-6
PMCID: PMC11072416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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