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PSEN1 Expression Identifies a Developmentally Distinct Favorable-Prognosis State in SHH α Medulloblastoma

2026-08-24

Abstract excerpt

<h4>Background: </h4> Although PSEN1 is best known for its role in Alzheimer's disease, it also regulates neural development and cerebellar morphogenesis. Medulloblastoma (MB) is the most common malignant pediatric brain tumor and arises from disrupted cerebellar developmental programs. The clinical significance of PSEN1 in MB remains unknown. We investigated the prognostic value and transcriptional correlates of...

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Literature Corpus work
a1203a6c-4a2b-50b4-a0b1-bbdb66e9231e
DOI
10.64898/2026.08.21.746295
Open publication

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PSEN1 Expression Identifies a Developmentally Distinct Favorable-Prognosis State in SHH α MedulloblastomaDOI 10.64898/2026.08.21.746295
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