Article

Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

2023-09-13

Abstract excerpt

Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms of Neurodegeneration with Brain Iron Accumulation, caused by mutations in the gene encoding the autophagy-related protein, WDR45. The mechanisms linking autophagy, iron overload and neurodegeneration in BPAN are poorly understood and, as a result, there are currently no disease-modifying treatments for this progressive disorde...

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Literature Corpus work: a11ad13b-92e9-51d3-8f75-3d7aaaf36096
DOI: 10.1101/2023.09.13.556416

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