Article

The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin

2026-04-03

Abstract excerpt

Most proteins synthesized in the endoplasmic reticulum (ER) are covalently modified upon addition of pre-assembled oligosaccharides to side chains of asparagine (N) residues. Processing of N-linked oligosaccharides by ER-resident glucosidases, mannosidases and glucosyltransferases determines the fate of the associated polypeptides. Terminally glucose residues are removed from N-glycans to hamper engagement of ER-r...

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Literature Corpus work: a117d06b-2f25-589c-8572-323246e9d00c
DOI: 10.64898/2026.04.02.716018

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