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The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

7 Feb 2008

Abstract excerpt

Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is an autosomal dominant dementia that is characterized by the retention of polymers of neuroserpin as inclusions within the endoplasmic reticulum (ER) of neurons. We have developed monoclonal antibodies that detect polymerized neuroserpin and have used COS-7 cells, stably transfected PC12 cell lines and transgenic Drosophila melanogaster to...

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PMID: 18267959
DOI: 10.1093/hmg/ddn041

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The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIBPMID 18267959Read ↗

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