Article
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.
FEBS letters - 7 Sept 2001
Briand C, Kozlov S V, Sonderegger P, Grütter M G
Abstract excerpt
The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations...
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