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Article

Lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies.

Neurobiology of aging - 1 Oct 2014

Schipanski Angela, Oberhauser Felix, Neumann Melanie, Lange Sascha, Szalay Beata, Krasemann Susanne, van Leeuwen Fred W, Galliciotti Giovanna, Glatzel Markus

Abstract excerpt

A feature of neurodegenerative diseases is the intraneuronal accumulation of misfolded proteins. In familial encephalopathy with neuroserpin inclusion bodies (FENIB), mutations in neuroserpin lead to accumulation of neuroserpin polymers within the endoplasmic reticulum (ER) of neurons. Cell culture based studies have shown that ER-associated degradation (ERAD) is involved in clearance of mutant neuroserpin. Here,...

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Identifiers

PMID: 24795221
DOI: 10.1016/j.neurobiolaging.2014.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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