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Article

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

The Journal of biological chemistry - 21 Aug 2009

Kroeger Heike, Miranda Elena, MacLeod Ian, Pérez Juan, Crowther Damian C, Marciniak Stefan J, Lomas David A

Abstract excerpt

The serpinopathies are a family of diseases characterized by the accumulation of ordered polymers of mutant protein within the endoplasmic reticulum. They are a diverse group including alpha(1)-antitrypsin deficiency and the inherited dementia familial encephalopathy with neuroserpin inclusion bodies or FENIB. We have used transient transfection of COS7 cells and mouse embryonic fibroblasts, PC12 cell lines that...

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Identifiers

PMID: 19549782
DOI: 10.1074/jbc.M109.027102
PMCID: PMC2755687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.PMID 19549782Read ↗

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