Article
Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2008
Hansen M, Baunsgaard D, Autrup H, Vogel U B, Møller P, Lindecrona R, Wallin H, Poulsen H E, Loft S, Dragsted L O
Abstract excerpt
We have shown previously that a high sucrose intake increases the background level of somatic mutations and the level of bulky DNA adducts in the colon epithelium of rats. The mechanism may involve either glucose or fructose formed by hydrolysis of sucrose. Male Big Blue rats were fed 30% sucrose, glucose, fructose or potato starch as part of the diet. Mutation rates and bulky DNA adduct levels were determined in...
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