Article

Bayesian Estimation of Muscle Mechanisms and Therapeutic Targets Using Variational Autoencoders

2024-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Cardiomyopathies, often caused by mutations in genes encoding muscle proteins, are traditionally treated by phenotyping hearts and addressing symptoms post irreversible damage. With advancements in genotyping, early diagnosis is now possible, potentially introducing earlier treatment. However, the intricate structure of muscle and its myriad proteins make treatment predictions challenging. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a1050598-7ef8-57d4-904b-764abadd5716
DOI: 10.1101/2024.05.08.593035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bayesian Estimation of Muscle Mechanisms and Therapeutic Targets Using Variational AutoencodersDOI 10.1101/2024.05.08.593035Read

Bayesian estimation of muscle mechanisms and therapeutic targets using variational autoencoders.Semantic proximity Read

Machine learning meets Monte Carlo methods for models of muscle's molecular machinery to classify mutations.Semantic proximity Read

Computational tool to study perturbations in muscle regulation and its application to heart diseaseSemantic proximity Read

Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease.Semantic proximity Read

On the use of variational autoencoders for biomedical data integrationSemantic proximity Read

Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generationSemantic proximity Read

Rapidly Inferring Personalized Neurostimulation Parameters with Meta-Learning: A Case Study of Individualized Fiber Recruitment in Vagus Nerve StimulationSemantic proximity Read

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological rolesSemantic proximity Read

The effect of variable troponin C mutation thin filament incorporation on cardiac muscle twitch contractions.Semantic proximity Read

Deep Learning Models Capture Umbrella Sampling-Derived Energetic Trends: A Troponin C Case Study.Semantic proximity Read

Phenotype- and patient-specific modelling in asthma: Bronchial thermoplasty and uncertainty quantification.Semantic proximity Read

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.Semantic proximity Read