Alzheimer related genes show accelerated evolution

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder of unknown cause with complex genetic and environmental traits. Here, we show that gene structures of loci, that show AD-associated changes in their expression, evolve faster than the genome at large. This phylogenetic trait of AD suggests a critical pathogenetic role of recent adaptive evolution of human brain and might have far reaching consequences with r...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Apolipoproteins E
• Bioinformatics and Genomic Networks
• Gene expression and cancer classification
• Machine Learning in Bioinformatics
• Mutation

Identifiers and source

Literature Corpus work

a0e0dda4-2d19-5173-a0c4-272413a814a2

DOI

10.1101/114108