Article

Adaptation and Selection Shape Clonal Evolution During Residual Disease and Recurrence

2020-04-24

Abstract excerpt

<h4>Summary</h4> The survival of residual tumor cells following therapy and their eventual recurrence constitutes one of the biggest obstacles to obtaining cures in breast cancer, but it remains unclear how the clonal composition of tumors changes during tumor relapse. We used cellular barcoding to directly monitor clonal dynamics during tumor recurrence in a genetically engineered mouse model. We found that the...

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Literature Corpus work: 4464617a-fb0b-5698-976e-2b124e8a9b14
DOI: 10.1101/2020.04.22.055780

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