Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

Abstract excerpt

Recurrent breast cancer accounts for most disease-associated mortality and can develop decades after primary tumor therapy. Recurrences arise from residual tumor cells (RTCs) that can evade therapy in a dormant state, however the mechanisms are poorly understood. CRISPR-Cas9 screening identified the transcription factors SOX5/6 as functional regulators of tumor recurrence. Loss of SOX5 accelerated recurrence and p...

Topics

Open a Topic to create a Post that cites this publication.

• Breast Cancer Treatment Studies
• Breast Neoplasms
• Cancer Cells and Metastasis
• Cell Line, Tumor
• Gene Expression
• Mice
• Neoplasm Recurrence, Local
• Phenotype

Identifiers and source

Literature Corpus work

13c65885-42bb-58ba-a1a6-c262e62d8e2e

DOI

10.1101/2025.05.07.652632