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Article

Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges.

The ISME journal - 1 Sept 2013

Woodhouse Jason N, Fan Lu, Brown Mark V, Thomas Torsten, Neilan Brett A

Abstract excerpt

The biosynthesis of non-ribosomal peptide and polyketide natural products is facilitated by multimodular enzymes that contain domains responsible for the sequential condensation of amino and carboxylic subunits. These conserved domains provide molecular targets for the discovery of natural products from microbial metagenomes. This study demonstrates the application of tag-encoded FLX amplicon pyrosequencing...

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Identifiers

PMID: 23598791
DOI: 10.1038/ismej.2013.65
PMCID: PMC3749504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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