Article

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8 <sup>+</sup> T cell killing in colorectal cancer

2022-05-13

Abstract excerpt

Efficacy of immunotherapy is limited in patients with colorectal cancer (CRC) because high expression of tumor-derived transforming growth factor (TGF)-β pathway molecules and interferon (IFN)-stimulated genes (ISGs) promotes tumor immune evasion. Here, we identified a long noncoding RNA (lncRNA), VPS9D1-AS1, which was located in ribosomes and amplified TGF-β signaling and ISG expression. We show that high express...

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Literature Corpus work: a0705f37-772b-519c-8c45-237990c5633a
DOI: 10.1101/2022.05.12.491618

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