Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of Evi‐1 oncoprotein represses TGF‐β signaling in colorectal cancer

7 Dec 2011

Abstract excerpt

Human colorectal cancer (CRC) cells are resistant to the anti-proliferative effect of transforming growth factor-β (TGF-β), suggesting that disruption of TGF-β signaling plays an important role in colorectal carcinogenesis. Ecotropic virus integration site-1 (Evi-1) oncoprotein represses TGF-β signaling by interacting with Smads, but its role in CRC has not been established. The purpose of this study is to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22161860
DOI: 10.1002/mc.21852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of Evi‐1 oncoprotein represses TGF‐β signaling in colorectal cancerPMID 22161860Read ↗

Molecular Characteristics, Oncogenic Roles, and Relevant Immune and Pharmacogenomic Features of EVA1B in Colorectal CancerSemantic proximity Read ↗

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancerSemantic proximity Read ↗

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8 <sup>+</sup> T cell killing in colorectal cancerSemantic proximity Read ↗

Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal CancerSemantic proximity Read ↗

Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer.Semantic proximity Read ↗

The expression of lncRNAs EVADR and LUESCC in Colorectal tumor tissues and their association with the CRC risk in an Iranian populationSemantic proximity Read ↗

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3Semantic proximity Read ↗

Egr‑1 inhibits colon cancer cell proliferation, migration and invasion via regulating CDKL1 at the transcriptional levelSemantic proximity Read ↗

ETV7 promotes colorectal cancer progression through upregulation of IFIT3Semantic proximity Read ↗

Prevalence of human cytomegalovirus in colorectal cancer and viral gene expression profilesSemantic proximity Read ↗

Oncogenic Ras and Transforming Growth Factor-β Synergistically Regulate AU-Rich Element–Containing mRNAs during Epithelial to Mesenchymal TransitionSemantic proximity Read ↗

Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.