Article

Evidence of Increased Hemangioblastic and Early Hematopoietic Potential in Chronic Myeloid Leukemia (CML)-derived Induced Pluripotent Stem Cells (iPSC)

2020-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Hemangioblasts derived from mesodermal lineage are the earliest precursors of hematopoietic stem cells and endothelial cells. Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) are the only experimental systems in which these cells can be assayed and quantified. We show here using CML-derived iPSC and blast-cell colony forming (Bl-CFC) assays that hemangioblasts are highly expa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ff55766-ce72-5eca-9384-46946ff52cd5
DOI: 10.1101/2020.06.17.140202

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest

Evidence of Increased Hemangioblastic and Early Hematopoietic Potential in Chronic Myeloid Leukemia (CML)-derived Induced Pluripotent Stem Cells (iPSC)DOI 10.1101/2020.06.17.140202Read

Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) using patient-derived induced pluripotent stem cells (iPSC)Semantic proximity Read

Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristicsSemantic proximity Read

TGF- 1-induced PI3K/Akt/NF- B/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblastsSemantic proximity Read

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samplesSemantic proximity Read

Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemiaSemantic proximity Read

Checkpoint kinase 1 is essential for establishing fetal haematopoiesis and hematopoietic stem and progenitor cell survivalSemantic proximity Read

Basic fibroblast growth factor positively regulates hematopoietic development.Semantic proximity Read

Inhibition of farnesyltransferase activity diminishes hematopoietic stem cell <i>ex vivo</i> expansion abilitySemantic proximity Read

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cellsSemantic proximity Read

BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels.Semantic proximity Read