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Article

Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia

28 Oct 2009

Abstract excerpt

Hairy enhancer of split 1 (Hes1) is a basic helix-loop-helix transcriptional repressor that affects differentiation and often helps maintain cells in an immature state in various tissues. Here we show that retroviral expression of Hes1 immortalizes common myeloid progenitors (CMPs) and granulocyte-macrophage progenitors (GMPs) in the presence of interleukin-3, conferring permanent replating capability on these...

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PMID: 19861684
DOI: 10.1182/blood-2009-05-222836

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