Article

Mitosis can drive cell cannibalism through entosis.

2017-07-11

Abstract excerpt

Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA ac...

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Literature Corpus work: 9fec3daf-2944-58a4-b443-9d8977a1c382
DOI: 10.17863/cam.41122

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