Article
Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes
2021-04-28
Abstract excerpt
The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer´s disease (AD) that coexist with vascular disease. Although olfactory dysfunction is considered a clinical sign of AD-related de-mentias, little is known about the impact of this sensorial impairment in MixD at molecular level. To address this gap in knowledge, we have assessed olfactory bulb (...
Topics
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- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Dementia and Cognitive Impairment Research
- Medicinal Plants and Neuroprotection
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
Identifiers and source
- Literature Corpus work
- 9fe87922-c358-580f-b497-92e42c427ff2
- DOI
- 10.20944/preprints202104.0748.v1