Article
Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2005
Ali M Monsur, Nagatsugi Fumi, Nakayama Shizuka, Alam M Rowshon, Kawasaki Takeshi, Sasaki Shigeki
Abstract excerpt
Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific...
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