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Article

G-quadruplex ligands mediate downregulation of DUX4 expression

3 Mar 2020

Abstract excerpt

Abnormal DUX4 expression in skeletal muscles plays a key role in facioscapulohumeral muscular dystrophy (FSHD) pathogenesis, although the molecular mechanisms regulating DUX4 expression are not fully defined. Using bioinformatic analysis of the genomic DUX4 locus, we have identified a number of putative G-quadruplexes (GQs) forming sequences. Their presence was confirmed in synthetic oligonucleotiode sequences...

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PMID: 32182342
DOI: 10.1093/nar/gkaa146

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