Article

Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Fast twitch, type II muscle fibers are particularly prone to degradation in skeletal muscle pathologies, such as sarcopenia and muscular dystrophies. We previously showed that endogenous activation of the exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis. In the present study, we identify an independent pro-myogenic element within human CYTOR and optimize its RNA delivery...

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Literature Corpus work: a526e96e-7517-5b63-99ff-01e0992fa154
DOI: 10.1101/2025.01.17.633605

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