Article
Targeting effector pathways in RAC1P29S-driven malignant melanoma.
Small GTPases - 1 Jul 2021
Uribe-Alvarez Cristina, Guerrero-Rodríguez Sandra Lucía, Rhodes Jennifer, Cannon Alexa, Chernoff Jonathan, Araiza-Olivera Daniela
Abstract excerpt
Malignant melanoma is characterized by mutations in a number of driver genes, most notably BRAF and NRAS. Recent genomic analyses revealed that 4-9% of sun-exposed melanomas bear activating mutations in RAC1, which encodes a small GTPase that is known to play key roles in cell proliferation, survival, and migration. The RAC1 protein activates several effector pathways, including Group A p21-activated kinases...
Topics
- Animals
- Apoptosis
- Cell Proliferation
- Embryo, Nonmammalian
- Enzyme Inhibitors
- Gene Expression Regulation, Neoplastic
- Humans
- Melanoma
- Mutation
- Phosphatidylinositol 3-Kinases
- Serum Response Factor