Article

Hepatic Nrf1 ( <i>Nfe2l1</i> ) promotes VLDL dependent liver defense against sepsis

2024-07-08

Abstract excerpt

Sepsis causes mortality by triggering organ damage. Interest has emerged in stimulating disease tolerance to reduce organ damage. Liver plays a role in disease tolerance by mediating defensive adaptations, but sepsis-induced liver damage limit these effects. Here, we investigated whether stress defending transcription factors nuclear factor erythroid 2 related factor-1 (Nrf1) and -2 (Nrf2) in hepatocytes protect a...

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Identifiers and source

Literature Corpus work: 9f5ee270-a3d0-53cf-9ac3-313fcbfd2b21
DOI: 10.1101/2024.07.04.602118

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