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Article

Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

1 Apr 2023

Abstract excerpt

Hepatic cholesterol overload promotes steatohepatitis. Insufficient understanding of liver stress defense impedes therapy development. Here, we elucidate the role of stress defense transcription factors, nuclear factor erythroid 2 related factor-1 (NRF1) and -2 (NRF2), in counteracting cholesterol-linked liver stress. Using a diet that increases liver cholesterol storage, expression profiles and phenotypes of...

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PMID: 37060561
DOI: 10.1016/j.celrep.2023.112399

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