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Article

Network integration and modelling of dynamic drug responses at multi-omics levels

15 Oct 2020

Abstract excerpt

Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized by integrating the molecular activities in networks of interacting proteins. As proof-of-concept we challenge network modeling with time-resolved proteome, transcriptome and methylome measurements in iPSC-derived human 3D cardiac microtissues to elucidate adverse...

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PMID: 33060801
DOI: 10.1038/s42003-020-01302-8

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