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Article

RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events

2024-06-21

Abstract excerpt

<h4>Background</h4> Hematopoietic transcription factor RUNX1 is expressed from proximal P2 and distal P1 promoter to yield isoforms RUNX1 B and C, respectively. The roles of these isoforms in RUNX1 autoregulation and downstream-gene regulation in megakaryocytes and platelets are unknown. <h4>Objectives</h4> To understand the regulation of RUNX1 and its target genes by RUNX1 isoforms. <h4>Methods</h4> We perform...

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Literature Corpus work
9f02f3f6-8c8e-54db-afd8-3a61bfa81d9a
DOI
10.1101/2024.06.18.599563
Open publication

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RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular EventsDOI 10.1101/2024.06.18.599563
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