Altered gut microbiota mediates the association between APOE genotype and amyloid-β accumulation in middle-aged adults.

doi:10.1007/s00415-025-13412-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Altered gut microbiota mediates the association between APOE genotype and amyloid-β accumulation in middle-aged adults.

Journal of neurology - 2 Oct 2025

Wadop Yannick N, Bernal Rebecca, Njamnshi Wepnyu Y, Satizabal Claudia L, Beiser Alexa, Ruiz Agustin, Njamnshi Alfred K, Vasan Ramachandran S, Seshadri Sudha, Himali Jayandra Jung, Fongang Bernard

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for Alzheimer's disease, yet the mechanisms linking APOE to amyloid-β (Aβ) pathology remain incompletely understood. Emerging evidence suggests that the gut microbiome may modulate neurodegeneration; however, its role as a mediator in the APOE-Aβ relationship remains unclear. OBJECTIVE: Evaluate whether specific microbial taxa...

Read the complete abstract on PubMed

Topics

Humans
Gastrointestinal Microbiome
Male
Female
Middle Aged
Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apolipoprotein E4

Apolipoproteins E

Dysbiosis

Alzheimer Disease

Aged

Genotype

Brain

Source

Open in PubMed Open full text

Identifiers

PMID: 41037094
DOI: 10.1007/s00415-025-13412-6
PMCID: PMC12491116

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered gut microbiota mediates the association between APOE genotype and amyloid-β accumulation in middle-aged adults.PMID 41037094Read ↗

Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-β Accumulation in Middle-Aged AdultsSemantic proximity Read ↗

Association between Apolipoprotein E genotype and the gut microbiome composition in humans and miceSemantic proximity Read ↗

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiologySemantic proximity Read ↗

APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer DiseaseSemantic proximity Read ↗

The impact of APOE genotype, age, and sex on gut microbiota in a mouse model of Alzheimer's Disease: an exploration of their interactions.Semantic proximity Read ↗

The Microbiota–Gut–Brain Axis in Alzheimer’s Disease: A Review of Taxonomic Alterations and Potential Avenues for InterventionsSemantic proximity Read ↗

Correlation between APOE4 gene and gut microbiota in Alzheimer’s diseaseSemantic proximity Read ↗

The Gut-Brain Axis in Alzheimer’s Disease: Microbiota as a Key Contributor to Disease PathogenesisSemantic proximity Read ↗

Gut microbiome alterations in Alzheimer’s diseaseSemantic proximity Read ↗

Exploring the relationship between APOEε4 allele and gut microbiota composition and function in healthy adultsSemantic proximity Read ↗

Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s diseaseSemantic proximity Read ↗

Gut microbiome alterations in preclinical Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.