Article

scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy

2025-03-19

Abstract excerpt

TDP-43 proteinopathies are a set of neurological disorders characterized by the abnormal accumulation and mislocalization of TDP-43 in the cytoplasm, leading to the disruption of the normal function of the protein. In most of the cases, it is the wildtype (wt) form of the protein that is involved. An untargeted high-throughput screen of a single-chain variable fragment (scFv) library was performed using phage disp...

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Literature Corpus work: 9e93715d-58cb-50a2-a9c4-50e4992112cc
DOI: 10.1101/2025.03.19.644089

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