Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.

BMC neuroscience - 4 Sept 2020

Venkataraman Lalitha, He Ping, Khan Galam, Harris Brent T, Sierks Michael R

Abstract excerpt

BACKGROUND: Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer's disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory, and behavior. Transactive response DNA-binding protein 43 (TDP-43) pathology is found in most FTD and ALS cases. It plays a role in transcription, translation and serves as a shuttle between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Specificity
Share to Biotinylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Immunoglobulin Fragments

Share to Immunohistochemistry

Share to Microscopy, Atomic Force

Share to Sensitivity and Specificity

Share to TDP-43 Proteinopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 32887544
DOI: 10.1186/s12868-020-00586-0
PMCID: PMC7472585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.PMID 32887544Read ↗

scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathySemantic proximity Read ↗

Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathologySemantic proximity Read ↗

Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice StudiesSemantic proximity Read ↗

Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43Semantic proximity Read ↗

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defectsSemantic proximity Read ↗

Development of a pan‐tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregatesSemantic proximity Read ↗

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defectsSemantic proximity Read ↗

Phage display derived peptides for Alzheimer's disease therapy and diagnosisSemantic proximity Read ↗

Structure of pathological TDP-43 filaments from ALS with FTLD.Semantic proximity Read ↗

Selective Targeting of Pathogenic Tau Seeds via a Novel VHHSemantic proximity Read ↗

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype.Semantic proximity Read ↗

Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.