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Article

Autophagy-Related Beclin 1 and Head and Neck Cancers

1 Jun 2020

Abstract excerpt

Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and...

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PMID: 32669852
DOI: 10.2147/ott.s256072

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