Signatures of Micropeptides Encoded by lncRNAs in Cancer Progression and Metastasis

Abstract excerpt

Long non-coding RNAs (lncRNAs) are key regulators of gene expression, chromatin remodeling, and signaling. Recent estimates suggest that the human genome contains more than 35,000 lncRNA genes, with roughly 20% predicted to encode micropeptides (MPs) with unknown functions. In this study, we focused on the subset of lncRNAs with strong statistical evidence for MP-encoding potential, accounting for approximately 8%...

Topics

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• Phenotype
• Chromatin
• Genome
• Neoplasms
• RNA and protein synthesis mechanisms
• RNA, Long Noncoding
• Transcription, Genetic
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

9e3fc055-671d-5609-9bbc-cbf5f5d5711a

DOI

10.1101/2025.09.22.677872