Article
Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology.
Cold Spring Harbor perspectives in medicine - 5 Jul 2017
Schmitt Adam M, Chang Howard Y
Abstract excerpt
Although only 2% of the genome encodes protein, RNA is transcribed from the majority of the genetic sequence, suggesting a massive degree of cellular functionality is programmed in the noncoding genome. The mammalian genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which occur at disease-associated loci or are specifically expressed in cancer. Although the vast majority of lncRNAs have...
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