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Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer

1 Mar 2023

Abstract excerpt

Introduction: Ovarian cancer is one of the leading causes of death for women with cancer worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian cancer (HGSOC) are fulfilled by a combination of aerobic glycolysis and oxidative phosphorylation (OXPHOS). Although reduced OXPHOS activity has emerged as one of the significant contributors to tumor aggressiveness and chemoresistance,...

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PMID: 36937395
DOI: 10.3389/fonc.2023.1129352

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