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Article

Genetic assessment of the causal relationship between obstructive sleep apnea and pulmonary hypertension: Mendelian randomization and meta-analysis.

Respiratory medicine - 1 Jan 2026

Pang Lingpin, Du Shiyu, Wu Shuozhong, Xian Qian, Zeng Zihao, Guo Dingyu, Zhong Ming, Song Lingyue, Huang Zhihai, Liu Yiming, Yuan Tianhuan, Sun Xishi

Abstract excerpt

BACKGROUND AND OBJECTIVE: Clinical observational studies have suggested a complex association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), but the causal relationship remains unclear due to the influence of confounding factors. In this study, a bidirectional two-sample Mendelian randomization (MR) analysis was conducted to investigate whether the association between OSA and PH is causal....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 41812932
DOI: 10.1016/j.rmed.2026.108760

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