Article

TGF-β downregulates antigen processing and presentation genes and MHC I surface expression through a Smad3-dependent mechanism

2023-02-01

Abstract excerpt

Regulation of MHC I surface expression by TGF-β is important for controlling cell-mediated immune responses, but how TGF-β downregulates MHC I is unknown. We investigated this mechanism using flow cytometry and RNA-sequencing to identify the major TGF-β signaling pathway and target genes involved. All three isoforms of TGF-β were found to have similar abilities to downregulate constitutive MHC I surface expression...

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Literature Corpus work: 9e1c69d9-a6d4-5890-8385-924f01b21e52
DOI: 10.1101/2023.01.30.526196

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